The mixture screw is only really relevant at tickover / low revs.
http://www.youtube.com/watch?v=qUzu6ZkeFTw#action=share
Whether it is a fuel or air screw depends on the position relative to the slide and that will impact in which direction you turn it to richen or lean the mixture at tickover.
Looking at the plug after a run really doesn't tell you much about the condition at various throttle positions during the run. It can look spot on if you're pooling about at 1/4 throttle but go to hell as soon as you roll it on.
Google, or search on here, how to do plug chops and check your jetting at all possible throttle positions.
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