I've found on the Mikuni 35 & 38 TMX carbs that i've dynoed that the balance between rich/lean bottom-end/top-end can be difficult to achieve.
For example, when dynoing my racer, i found that when the top-end rev range was spot on, i had a massive lean spot in the mid-range. So to iron out the mid-range lean spot, i had to retain the 360 main jet i was using, but go to the
leanest needle i could get, so that i could find a main-jet/needle combo that allowed me to run the needle on the middle clip.
On testing other Mikunis, i found that running on the top clip, and sometimes even the 2nd clip, meant that the needle wasnt lifted sufficiently to allow the taper on the needle to flow sufficiently in the mid range. The first part of a Mikuni needle is straight followed by two tapered sections of increasing steepness. You need to make sure that when your powerband is coming on song, that the tapered part of the needle is in play, so that it can feed the fuel through and avoid lean running mid-range. Running a Mikuni on top clip doesnt usually allow this to happen, and teh mid range is still using either the straight or less tapered part of the needle, which can lead to disaster, depending on how the rest of the engine is set up, second clip is an improvement.....but for safety, i personally prefer middle clip if you can live with feeding the throttle on.
It doesnt necessarily feel crisp when accellerating, in fact on the racer i have to 'feed' the throttle on to avoid bogging, but i'd rather do that than have a big lean spot in my mid-range. Imagine hooning down a long straight (or a long road) working your engine to the max.....and then rolling off the throttle into a lean spot!
A Mikuni TM24mm has a needle jet that you can richen up on the mid range (QO being the standard lean item, Q2, Q4, Q6 etc getting richer) TMX 35 & 38 don't have these, and so mid-range can be more difficult to dial in without compramise somewhere. A Dellortto of equivalent size has more adjustments to dial in and doesnt flow as well as a Mikuni.....but in the end, because it has more adjustments you can get it closer to ideal rich/lean running throughout the entire rev range. (In my humble opinion)
So working with your Mikuni on the RB, i would be tempted to experiment with a couple of different set-ups.....maybe drop the pilot a size, increase the needle to a leaner item (56, or 57?....maybe even a 58?), but put the needle on the middle clip, and play with the main jet until its dialled in.
Do some runs and plug chops and see what you think.
Let us know how you get on.